The Spaniard went out with a whimper, losing 6-3 6-2 to Croatian Ivan Dodig.
Fifth seed Florian Mayer also had a tough time of it in his opening match, but did at least survive.
The German needed almost two and a half hours to see off wild card Franco Skugar 3-6 6-3 7-6 (8/6).
Michael Berrer, seeded eighth, had no such troubles, seeing off Nikola Mektic 7-5 6-1, while Lukas Lacko came from behind to beat Marsel Ilhan 4-6 6-4 7-5